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Assistant Professor, Baylor College of Medicine
Ph.D., Max-Delbruck Centrum and Free University, Berlin, Germany, 2004
Postdoc, Harvard University, Boston, MA, 2005-12
Pluripotent stem cells for human development and metabolic diseases
We are applying pluripotent stem cell technology to study human embryogenesis and for metabolic disease modeling. We combine stem cell, developmental and chemical biology with novel molecular approaches and tissue engineering to generate cell type of interest from patient-specific IPS and embryonic stem cells.
Selected Publications
Osafune K, Caron L, Borowiak M, Martinez RJ, Fitz-Gerald CS, Sato Y, Cowan CA, Chien KR, Melton DA (2008) Marked differences in differentiation propensity among human embryonic stem cell lines. Nature Biotechnology 26:313-315.
Chen S, Borowiak M, Fox JL, Maehr R, Osafune K, Davidow L, Lam K, Peng LF, Schreiber SL, Rubin LL, Melton D (2009) A small molecule that directs differentiation of human ESCs into the pancreatic lineage. Nature Chemical Biology 5:258-265.
Borowiak M, Maehr R, Chen S, Chen AE, Tang W, Fox JL, Schreiber SL, Melton DA (2009) Small molecules efficiently direct endodermal differentiation of mouse and human embryonic stem cells. Cell Stem Cell 4:348-358.
Borowiak M, Melton DA (2009) How to make beta cells? Current Opionion in Cell Biology 21:727-732.
Borowiak M (2010) The new generation of beta-cells: replication, stem cell differentiation, and the role of small molecules. The Review of Diabetic Studies 7:93-104.
Sneddon JB*, Borowiak M*, Melton DA (2012) Self-renewal of embryonic-stem-cell-derived progenitors by organ-matched mesenchyme. Nature 491:765-768.
Chen AE*, Borowiak M*, Sherwood RI, Kweudjeu A, Melton DA (2013) Functional evaluation of ES cell-derived endodermal populations reveals differences between Nodal and Activin A-guided differentiation. Development 140:675-686.
Contact Information
Malgorzata (Gosia) Borowiak, Ph.D.
Department of Molecular and Cellular Biology
Center for Cell and Gene Therapy
One Baylor Plaza N1020
Houston, Texas 77030, U.S.A.
Tel: (713) 798-7771
E-mail: